TDP-43 and concomitant neuropathologies among various racioethnic backgrounds

 


   Note: An Official Proposal has not been Submitted to NACC.


   Lead Investigator:    Brittany Dugger
   Institution      :    University of California Davis
   E-Mail           :    aescudero@ucdavis.edu
   Proposal ID      :    1697



   Proposal Description:
   Transactive Response DNA-binding protein 43 (TDP-43) is a nuclear protein that plays a critical role in ribonucleic acid (RNA) processing. Pathologic TDP-43 has been found in a wide range of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration (FTLD), and Hippocampal Sclerosis. Recently, it has also been found in a quarter of all patients with Alzheimer?s disease (AD). Using data from the National Alzheimer?s Coordinating Center (NACC), the purpose of my project is twofold: 1) Analyze TDP-43 prevalence amongst various racioethnic backgrounds of those with TDP-43 and AD and, 2) Compare AD cases with and without TDP-43 and assess the frequency of concomitant neuropathologies.